GHK-CU

This naturally occurring copper peptide occurs in human plasma; However, as people age, they lose the capacity for production. This tripeptide GHK- CU helps activate wound healing, regulate immune response, act as an anti-inflammatory and antioxidant, and stimulate collagen synthesis. Research points to GHK-CU helping to modulate gene expression with anti-aging benefits.

Properties:

• MW= 403.9242 g/mol

• Naturally occurring copper complex of GLYCYL-L-HISTIDYL-L-LYSINE peptide.

• Has a high affinity for copper

• First isolated from human plasma, but also found in saliva and urine

• We lose GHK as we age; at age 20, the plasma level of GHK is about 200ng/ml. By age 60, it declines to 80ng/ml.

• Decline in GHK coincides with a noticeable decrease in the rejuvenative capacity of an organism

Applications:

• Activates wound healing, including gastric

• attracts immune cells

• Is an antioxidant

• Is an anti- inflammatory

• Stimulates collagen and glycosaminoglycan synthesis in skin fibroblasts

• Modulates the activity of both metalloproteinases and their inhibitors

• Improves stem cells

• Defends against tumors

• Restores replicative vitality to fibroblasts after radiation therapy

• Helps regenerate skin; useful for diabetic skin ulcers

In cosmetic products, GHK has been reported to

• Stimulate hair growth

• Tighten loose skin

• Improve elasticity

• Improve skin density and firmness

• Reduce fine lines and wrinkles

• Reduce photodamage and hyperpigmentation

• Stimulate nail growth.

Dosage:

• 1 to 2mg/day for 6-week intervals

• can be utilized 3 to 4 times a year

Possible Side Effects:

• A possibility of copper toxicity; monitor carefully

• The lunula of the nail turns blue (correct over 4 to 6 weeks)

• Mild skin irritation (rare, <3% of users)

• Temporary copper taste when administered systemically

• Possible allergic reaction to copper (very rare)

• Minor redness at the injection site

• Temporary skin sensitivity to sunlight

• Mild burning sensation upon initial topical application

• Rare cases of contact dermatitis

• Potential blue-green staining at high concentrations

Side Effect Management Strategies:

• Nausea: Take with food, smaller meals, and ginger supplements

• Vomiting: Slower dose escalation, anti-emetics if severe

• Diarrhea: Adequate hydration, probiotics, bland diet

• Constipation: Increase fiber intake, adequate fluids, and light exercise

DO NOT USE:

CONTRAINDICATIONS

• • Wilson's disease or copper metabolism disorders

• • Known allergy to copper compounds

• • Severe liver dysfunction

• • Active skin infections at the application site